Pharmacokinetic model-controlled infusion of midazolara

Target controlled infusion of rocuronium: analysis of effect data to select a pharmacokinetic model.

BACKGROUND We aimed to evaluate whether area under the curve (AUC) analysis of pharmacodynamic data can be used to compare pharmacokinetic models taken from the literature, during a target controlled infusion (TCI) of rocuronium. METHODS Seventy-two patients scheduled for orthopaedic surgery received a TCI of rocuronium (Stanpump) based on one of four pharmacokinetic models: those described b...

A prospective evaluation of pharmacokinetic model controlled infusion of propofol in paediatric patients.

We have tested a published algorithm for pharmacokinetic model controlled infusion of propofol to supplement 67% nitrous oxide for general anaesthesia in Chinese children aged 4-10 yr. Initially we studied 10 children undergoing minor procedures with spontaneous ventilation; mean duration of surgery was 38 min and mean propofol infusion rate 497 micrograms kg-1 min-1. The precision of the model...

A pharmacokinetic-pharmacodynamic model for duodenal levodopa infusion.

OBJECTIVE The purpose of this work was to identify and estimate a population pharmacokinetic- pharmacodynamic model for duodenal infusion of a levodopa/carbidopa gel (Duodopa) to examine pharmacological properties of this treatment. METHODS The modeling involved pooling data from 3 studies (on advanced Parkinson disease) and fixing some parameters to values found in literature. The first stud...

Cross-simulation between two pharmacokinetic models for the target-controlled infusion of propofol

BACKGROUND We investigated how one pharmacokinetic (PK) model differed in prediction of plasma (C(p)) and effect-site concentration (C(eff)) using a reproducing simulation of target-controlled infusion (TCI) with another PK model of propofol. METHODS Sixty female patients were randomly assigned to TCI using Marsh PK (Group M) and TCI using Schnider PK (Group S) targeting 6.0 µg/ml of C(p) of ...

Target Controlled Infusion (TCI)